Assay Detail
Binding
CHEMBL744041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for blocking activity on Muscarinic acetylcholine receptor in guinea pig atria
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.79 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.69 |
| CHEMBL500996 | METHOCTRAMINE HYDROCHLORIDE | — | 1 | 8.13 |
| CHEMBL1202789 | — | — | 1 | 7.96 |
| CHEMBL1202787 | — | — | 1 | 7.80 |
| CHEMBL1202786 | — | — | 1 | 7.71 |
| CHEMBL541116 | — | — | 1 | 7.35 |
| CHEMBL1204259 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 2.042 | nM | 8.69 |
| CHEMBL500996 | METHOCTRAMINE HYDROCHLORIDE | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL1202789 | — | Kd | = | 10.96 | nM | 7.96 |
| CHEMBL1202787 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL1202786 | — | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL541116 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL1204259 | — | Kd | = | 134.9 | nM | 6.87 |