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Compound Detail

CHEMBL1204259

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COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC.Cl.Cl.Cl.Cl

Basic Information

ChEMBL ID CHEMBL1204259
Phase Preclinical
Structure Type MOL
InChI Key SGALUKBJRAQPTI-UHFFFAOYSA-N
Parent Compound CHEMBL302179
Active Moiety CHEMBL302179
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

554.9
MW (Da)
6.44
ALogP
6
HBA
4
HBD
66.6
PSA (Ų)
0.10
QED
2
Ro5 Violations
27
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H62Cl4N4O2
MW 700.71
Aromatic Rings 2
Heavy Atoms 40
NP-Likeness -0.22

Activity Summary

Kd 3 meas. best 6.87

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL2094109
Kd 6.87 6.87 134.9 1
Muscarinic acetylcholine receptor
CHEMBL1907609
Kd 5.57 5.43 2691.5 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3806594 10.1021/jm00384a034 Muscarinic acetylcholine receptor 3
3806594 10.1021/jm00384a034 Unchecked 3

Data from ChEMBL 36 via Core Engine