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Compound Detail

CHEMBL1202789

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COc1ccccc1CNCCCCCCNCCCCCCCCCNCCCCCCN(N)Cc1ccccc1OC.Cl.Cl.Cl.Cl

Basic Information

ChEMBL ID CHEMBL1202789
Phase Preclinical
Structure Type MOL
InChI Key JMHQUDPHMWRXON-UHFFFAOYSA-N
Parent Compound CHEMBL303589
Active Moiety CHEMBL303589
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

612.0
MW (Da)
7.20
ALogP
7
HBA
4
HBD
83.8
PSA (Ų)
0.04
QED
2
Ro5 Violations
30
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H69Cl4N5O2
MW 757.80
Aromatic Rings 2
Heavy Atoms 44
NP-Likeness -0.36

Activity Summary

Kd 3 meas. best 7.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL2094109
Kd 7.96 7.96 11.0 1
Muscarinic acetylcholine receptor
CHEMBL1907609
Kd 6.08 5.945 831.8 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3806594 10.1021/jm00384a034 Muscarinic acetylcholine receptor 3
3806594 10.1021/jm00384a034 Unchecked 3

Data from ChEMBL 36 via Core Engine