Assay Detail
Binding
CHEMBL744763
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Affinity for human M1 cloned muscarinic receptor subtype expressed in CHO-K1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | — | 1 | 7.70 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 7.30 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | Ki | = | 19.8 | nM | 7.70 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 49.8 | nM | 7.30 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | Ki | = | 108.0 | nM | 6.97 |