Assay Detail
Functional
CHEMBL746007
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The compound was tested In vitro for the ability to inhibit electrically induced contractions of the mouse vas deferens
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.29 | 10.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3037874 | — | — | 1 | 10.25 |
| CHEMBL3084309 | — | — | 1 | 10.13 |
| CHEMBL2370368 | — | — | 1 | 9.89 |
| CHEMBL2370366 | — | — | 1 | 9.49 |
| CHEMBL2370370 | — | — | 1 | 9.12 |
| CHEMBL2370362 | — | — | 1 | 8.20 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 7.94 |
| CHEMBL2370369 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3037874 | — | IC50 | = | 0.0564 | nM | 10.25 |
| CHEMBL3084309 | — | IC50 | = | 0.0745 | nM | 10.13 |
| CHEMBL2370368 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL2370366 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL2370370 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL2370362 | — | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2370369 | — | IC50 | > | 2040.0 | nM | - |
| CHEMBL2370369 | — | IC50 | > | 4240.0 | nM | - |