Assay Detail
Binding
CHEMBL747003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.74 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | — | 1 | 6.98 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | — | 1 | 6.74 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 313.0 | nM | 6.50 |