Assay Detail
Binding
CHEMBL748203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against guinea pig ileum using [3H]N-methylscopolamine
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.29 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298085 | — | — | 1 | 8.09 |
| CHEMBL47650 | — | — | 2 | 7.41 |
| CHEMBL297683 | — | — | 1 | 7.39 |
| CHEMBL296895 | — | — | 1 | 7.23 |
| CHEMBL296633 | — | — | 1 | 7.07 |
| CHEMBL297276 | — | — | 2 | 7.04 |
| CHEMBL49576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298085 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL47650 | — | Ki | = | 38.6 | nM | 7.41 |
| CHEMBL297683 | — | Ki | = | 40.5 | nM | 7.39 |
| CHEMBL296895 | — | Ki | = | 59.4 | nM | 7.23 |
| CHEMBL296633 | — | Ki | = | 84.7 | nM | 7.07 |
| CHEMBL297276 | — | Ki | = | 92.2 | nM | 7.04 |
| CHEMBL47650 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL297276 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL49576 | — | Ki | > | 10000.0 | nM | - |