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Compound Detail

CHEMBL297683

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O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1

Basic Information

ChEMBL ID CHEMBL297683
Phase Preclinical
Structure Type MOL
InChI Key MHBGDNWDRYOZPX-QWAKEFERSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

463.3
MW (Da)
3.16
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H22INO3
MW 463.31
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.20

Activity Summary

Ki 3 meas. best 8.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL2672
Ki 8.34 8.34 4.6 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 8.05 8.05 9.0 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Ki 7.39 7.39 40.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7752195 10.1021/jm00010a016 Muscarinic acetylcholine receptor M1 1
7752195 10.1021/jm00010a016 Muscarinic acetylcholine receptor M2 1
7752195 10.1021/jm00010a016 Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine