Assay Detail
Binding
CHEMBL748226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.76 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47650 | — | — | 2 | 9.89 |
| CHEMBL296633 | — | — | 1 | 9.51 |
| CHEMBL296895 | — | — | 1 | 9.42 |
| CHEMBL297276 | — | — | 2 | 9.08 |
| CHEMBL298085 | — | — | 1 | 8.38 |
| CHEMBL49576 | — | — | 1 | 8.12 |
| CHEMBL297683 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47650 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL296633 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL296895 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL297276 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL47650 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL298085 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL49576 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL297683 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL297276 | — | Ki | = | 11.6 | nM | 7.94 |