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Assay Detail

CHEMBL749044

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Binding
Inhibitory activity against muscle Glycogen Phosphorylase b
18
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Muscle tissue
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glycogen phosphorylase, brain form (CHEMBL3856)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of d-gluco- and d-xylopyranosylidene-spiro-(thio)hydantoins and N-(d-glucopyranosyl) amides.
Somsák L, Kovács L, Tóth M, Osz E, Szilágyi L, Györgydeák Z, Dinya Z, Docsa T, Tóth B, Gergely P.
J Med Chem (2001) 44 : 2843 -2848
PubMed 11495595 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 4.88 5.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL97548 2 5.51
CHEMBL489798 1 5.29
CHEMBL3351143 2 4.51
CHEMBL3351140 2 4.09
CHEMBL329692 1 -
CHEMBL1222250 DEXTROSE 4.0 1 -
CHEMBL95018 1 -
CHEMBL98177 1 -
CHEMBL99576 1 -
CHEMBL98182 1 -
CHEMBL97033 1 -
CHEMBL95888 1 -
CHEMBL317592 2 -
CHEMBL3349654 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL97548 Ki = 3100.0 nM 5.51
CHEMBL97548 Ki = 4200.0 nM 5.38
CHEMBL489798 Ki = 5100.0 nM 5.29
CHEMBL3351143 Ki = 31000.0 nM 4.51
CHEMBL3351143 Ki = 32000.0 nM 4.50
CHEMBL3351140 Ki = 81000.0 nM 4.09
CHEMBL329692 Ki = 440000.0 nM -
CHEMBL3349654 Ki = 710000.0 nM -
CHEMBL317592 Ki = 320000.0 nM -
CHEMBL317592 Ki = 105000.0 nM -
CHEMBL95888 Ki = 11500000.0 nM -
CHEMBL1222250 DEXTROSE Ki = 7400000.0 nM -
CHEMBL95018 Ki > 10000000.0 nM -
CHEMBL97033 Ki = 370000.0 nM -
CHEMBL98182 Ki = 1700000.0 nM -
CHEMBL99576 Ki = 3100000.0 nM -
CHEMBL98177 Ki > 10000000.0 nM -
CHEMBL3351140 Ki = 144000.0 nM -