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Assay Detail

CHEMBL749223

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Affinity for Muscarinic acetylcholine receptors in urinary bladder from Guinea Pig by (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB displacement.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Muscarinic acetylcholine receptor (CHEMBL2094109)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.
Johansson G, Sundquist S, Nordvall G, Nilsson BM, Brisander M, Nilvebrant L, Hacksell U.
J Med Chem (1997) 40 : 3804 -3819
PubMed 9371246 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.51 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL12980 QUINUCLIDINYL BENZILATE 1 9.70
CHEMBL517712 ATROPINE 4.0 1 8.80
CHEMBL122160 1 7.89
CHEMBL433672 1 7.54
CHEMBL121974 1 7.33
CHEMBL127659 1 7.19
CHEMBL333501 1 6.41
CHEMBL339405 1 6.30
CHEMBL339885 1 6.27
CHEMBL339305 1 6.17
CHEMBL341476 1 6.07
CHEMBL124395 1 5.89
CHEMBL125764 1 5.82
CHEMBL121945 1 5.75
CHEMBL125823 1 5.75
CHEMBL124564 1 5.60
CHEMBL332303 1 5.60
CHEMBL340597 1 5.41
CHEMBL125692 1 5.39
CHEMBL338561 1 5.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL12980 QUINUCLIDINYL BENZILATE Ki = 0.2 nM 9.70
CHEMBL517712 ATROPINE Ki = 1.6 nM 8.80
CHEMBL122160 Ki = 13.0 nM 7.89
CHEMBL433672 Ki = 29.0 nM 7.54
CHEMBL121974 Ki = 47.0 nM 7.33
CHEMBL127659 Ki = 64.0 nM 7.19
CHEMBL333501 Ki = 390.0 nM 6.41
CHEMBL339405 Ki = 500.0 nM 6.30
CHEMBL339885 Ki = 540.0 nM 6.27
CHEMBL339305 Ki = 670.0 nM 6.17
CHEMBL341476 Ki = 850.0 nM 6.07
CHEMBL124395 Ki = 1300.0 nM 5.89
CHEMBL125764 Ki = 1500.0 nM 5.82
CHEMBL121945 Ki = 1800.0 nM 5.75
CHEMBL125823 Ki = 1765.0 nM 5.75
CHEMBL124564 Ki = 2500.0 nM 5.60
CHEMBL332303 Ki = 2500.0 nM 5.60
CHEMBL340597 Ki = 3900.0 nM 5.41
CHEMBL125692 Ki = 4100.0 nM 5.39
CHEMBL338561 Ki = 5100.0 nM 5.29