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Compound Detail

CHEMBL339405

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Cc1ccc(C2=CN3CCC2CC3)s1

Basic Information

ChEMBL ID CHEMBL339405
Phase Preclinical
Structure Type MOL
InChI Key HNLUMKGZTQUVEY-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

205.3
MW (Da)
3.12
ALogP
2
HBA
0
HBD
3.2
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H15NS
MW 205.33
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -0.69

Activity Summary

Ki 4 meas. best 7.14

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL2094109
Ki 7.14 6.665 73.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9371246 10.1021/jm970346t Muscarinic acetylcholine receptor 5

Data from ChEMBL 36 via Core Engine