Assay Detail
Binding
CHEMBL749221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig.
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 7.17 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | — | 1 | 10.35 |
| CHEMBL331497 | — | — | 1 | 9.14 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.05 |
| CHEMBL123510 | — | — | 1 | 8.95 |
| CHEMBL338801 | — | — | 1 | 8.72 |
| CHEMBL339719 | — | — | 1 | 8.66 |
| CHEMBL339702 | — | — | 1 | 8.64 |
| CHEMBL333670 | — | — | 1 | 8.62 |
| CHEMBL128035 | — | — | 1 | 8.51 |
| CHEMBL124017 | — | — | 1 | 8.48 |
| CHEMBL122160 | — | — | 1 | 8.16 |
| CHEMBL124592 | — | — | 1 | 8.02 |
| CHEMBL333937 | — | — | 1 | 7.97 |
| CHEMBL333815 | — | — | 1 | 7.96 |
| CHEMBL333540 | — | — | 1 | 7.96 |
| CHEMBL433672 | — | — | 1 | 7.82 |
| CHEMBL121974 | — | — | 1 | 7.62 |
| CHEMBL124811 | — | — | 1 | 7.60 |
| CHEMBL127659 | — | — | 1 | 7.46 |
| CHEMBL125398 | — | — | 1 | 7.42 |
| CHEMBL126387 | — | — | 1 | 7.32 |
| CHEMBL340195 | — | — | 1 | 6.92 |
| CHEMBL124651 | — | — | 1 | 6.89 |
| CHEMBL341115 | — | — | 1 | 6.72 |
| CHEMBL333501 | — | — | 1 | 6.68 |
| CHEMBL338568 | — | — | 1 | 6.66 |
| CHEMBL124480 | — | — | 1 | 6.64 |
| CHEMBL339405 | — | — | 1 | 6.64 |
| CHEMBL124553 | — | — | 1 | 6.55 |
| CHEMBL339885 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | Ki | = | 0.045 | nM | 10.35 |
| CHEMBL331497 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL123510 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL338801 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL339719 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL339702 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL333670 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL128035 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL124017 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL122160 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL124592 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL333937 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL333815 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL333540 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL433672 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL121974 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL124811 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL127659 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL125398 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL126387 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL340195 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL124651 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL341115 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL333501 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL338568 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL124480 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL339405 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL124553 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL339885 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL341476 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL339305 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL433188 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL125560 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL121945 | — | Ki | = | 547.0 | nM | 6.26 |
| CHEMBL124395 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL125764 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL332303 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL125823 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL124332 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL332731 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL340597 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL124564 | — | Ki | = | 2530.0 | nM | 5.60 |
| CHEMBL123691 | — | Ki | = | 2840.0 | nM | 5.55 |
| CHEMBL125692 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL338561 | — | Ki | = | 3600.0 | nM | 5.44 |