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Compound Detail

CHEMBL123691

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COC(=O)c1coc(C2=CN3CCC2CC3)c1

Basic Information

ChEMBL ID CHEMBL123691
Phase Preclinical
Structure Type MOL
InChI Key KGQWSXHLBXVECT-UHFFFAOYSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

233.3
MW (Da)
2.13
ALogP
4
HBA
0
HBD
42.7
PSA (Ų)
0.73
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H15NO3
MW 233.27
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness 0.14

Activity Summary

Ki 3 meas. best 5.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL2094109
Ki 5.96 5.6833 1100.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9371246 10.1021/jm970346t Muscarinic acetylcholine receptor 3

Data from ChEMBL 36 via Core Engine