Assay Detail
Binding
CHEMBL749220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea Pig.
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 7.37 | 10.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | — | 1 | 10.29 |
| CHEMBL331497 | — | — | 1 | 9.57 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.49 |
| CHEMBL123510 | — | — | 1 | 9.10 |
| CHEMBL339719 | — | — | 1 | 9.02 |
| CHEMBL333670 | — | — | 1 | 8.81 |
| CHEMBL338801 | — | — | 1 | 8.68 |
| CHEMBL128035 | — | — | 1 | 8.62 |
| CHEMBL122160 | — | — | 1 | 8.55 |
| CHEMBL124017 | — | — | 1 | 8.38 |
| CHEMBL339702 | — | — | 1 | 8.30 |
| CHEMBL333937 | — | — | 1 | 8.24 |
| CHEMBL433672 | — | — | 1 | 8.19 |
| CHEMBL121974 | — | — | 1 | 8.13 |
| CHEMBL333540 | — | — | 1 | 8.11 |
| CHEMBL333815 | — | — | 1 | 8.09 |
| CHEMBL124592 | — | — | 1 | 8.08 |
| CHEMBL127659 | — | — | 1 | 7.92 |
| CHEMBL124811 | — | — | 1 | 7.80 |
| CHEMBL126387 | — | — | 1 | 7.77 |
| CHEMBL125398 | — | — | 1 | 7.23 |
| CHEMBL340195 | — | — | 1 | 7.22 |
| CHEMBL339405 | — | — | 1 | 7.14 |
| CHEMBL124480 | — | — | 1 | 7.03 |
| CHEMBL339305 | — | — | 1 | 7.00 |
| CHEMBL339885 | — | — | 1 | 6.89 |
| CHEMBL333501 | — | — | 1 | 6.85 |
| CHEMBL124651 | — | — | 1 | 6.75 |
| CHEMBL341115 | — | — | 1 | 6.64 |
| CHEMBL125764 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | Ki | = | 0.051 | nM | 10.29 |
| CHEMBL331497 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL123510 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL339719 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL333670 | — | Ki | = | 1.55 | nM | 8.81 |
| CHEMBL338801 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL128035 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL122160 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL124017 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL339702 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL333937 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL433672 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL121974 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL333540 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL333815 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL124592 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL127659 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL124811 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL126387 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL125398 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL340195 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL339405 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL124480 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL339305 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL339885 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL333501 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL124651 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL341115 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL125764 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL341476 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL121945 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL124553 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL125560 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL124395 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL338568 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL332303 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL332731 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL125823 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL433188 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL124332 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL124564 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL123691 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL340597 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL125692 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL338561 | — | Ki | = | 3320.0 | nM | 5.48 |