Assay Detail
Binding
CHEMBL751120
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Binding affinity for Opioid receptor delta 1 determined by displacing [3H]-DSLET from rat brain membrane binding sites
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.84 | 9.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538700 | — | — | 1 | 9.93 |
| CHEMBL2370502 | — | — | 1 | 9.41 |
| CHEMBL119590 | — | — | 1 | 9.35 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 8.60 |
| CHEMBL332803 | — | — | 1 | 8.52 |
| CHEMBL119535 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538700 | — | Ki | = | 0.118 | nM | 9.93 |
| CHEMBL2370502 | — | Ki | = | 0.393 | nM | 9.41 |
| CHEMBL119590 | — | Ki | = | 0.447 | nM | 9.35 |
| CHEMBL8234 | ENKEPHALIN | Ki | = | 2.53 | nM | 8.60 |
| CHEMBL332803 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL119535 | — | Ki | = | 61.0 | nM | 7.21 |