Assay Detail
Binding
CHEMBL751297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for the concentration required to inhibit [3H]CPP radioligand at EAA receptor sites in rat cortical membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.08 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280585 | — | — | 1 | 5.35 |
| CHEMBL420125 | — | — | 1 | 5.16 |
| CHEMBL112755 | — | — | 1 | 4.74 |
| CHEMBL112402 | — | — | 1 | - |
| CHEMBL323742 | — | — | 1 | - |
| CHEMBL325096 | — | — | 1 | - |
| CHEMBL286204 | QUINOLINIC ACID | — | 1 | - |
| CHEMBL113180 | — | — | 1 | - |
| CHEMBL323052 | — | — | 1 | - |
| CHEMBL418837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280585 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL420125 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL112755 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL112402 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL323742 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325096 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL286204 | QUINOLINIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL113180 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL323052 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL418837 | — | IC50 | > | 100000.0 | nM | - |