Assay Detail
Functional
CHEMBL753293
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Cytotoxicity against P388 leukemia
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204204 | — | — | 1 | 9.00 |
| CHEMBL553550 | — | — | 1 | 8.92 |
| CHEMBL1202602 | — | — | 1 | 8.52 |
| CHEMBL1202596 | — | — | 1 | 8.48 |
| CHEMBL1202597 | — | — | 1 | 8.39 |
| CHEMBL1202604 | — | — | 1 | 8.37 |
| CHEMBL541807 | — | — | 1 | 8.08 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 8.00 |
| CHEMBL557621 | — | — | 1 | 7.92 |
| CHEMBL555319 | — | — | 1 | 7.92 |
| CHEMBL552576 | — | — | 1 | 7.72 |
| CHEMBL541545 | — | — | 1 | 7.70 |
| CHEMBL540275 | — | — | 1 | 7.58 |
| CHEMBL553647 | — | — | 1 | 7.52 |
| CHEMBL544018 | — | — | 1 | 7.50 |
| CHEMBL539511 | — | — | 1 | 7.48 |
| CHEMBL1202599 | — | — | 1 | 7.43 |
| CHEMBL1202605 | — | — | 1 | 7.43 |
| CHEMBL1202603 | — | — | 1 | 7.40 |
| CHEMBL297274 | — | — | 1 | 7.30 |
| CHEMBL298087 | — | — | 1 | 7.30 |
| CHEMBL1202598 | — | — | 1 | 7.26 |
| CHEMBL538240 | — | — | 1 | 7.22 |
| CHEMBL541042 | — | — | 1 | 7.20 |
| CHEMBL539255 | — | — | 1 | 7.16 |
| CHEMBL1202595 | — | — | 1 | 7.00 |
| CHEMBL1202600 | — | — | 1 | 6.85 |
| CHEMBL543789 | — | — | 1 | 6.82 |
| CHEMBL556408 | — | — | 1 | 6.80 |
| CHEMBL540528 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204204 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL553550 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1202602 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1202596 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1202597 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1202604 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL541807 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL557621 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL555319 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL552576 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL541545 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL540275 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL553647 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL544018 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL539511 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1202599 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1202605 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1202603 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL298087 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL297274 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1202598 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL538240 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL541042 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL539255 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1202595 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1202600 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL543789 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL556408 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL540528 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1202601 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL556053 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL538490 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL554198 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL296551 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL541290 | — | IC50 | > | 1000.0 | nM | - |