Assay Detail
Binding
CHEMBL754606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding site
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.44 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | — | 1 | 8.60 |
| CHEMBL557035 | — | — | 1 | 8.52 |
| CHEMBL14887 | — | — | 1 | 7.99 |
| CHEMBL15100 | — | — | 1 | 7.88 |
| CHEMBL275670 | — | — | 1 | 7.76 |
| CHEMBL278891 | — | — | 1 | 7.63 |
| CHEMBL280264 | — | — | 1 | 7.55 |
| CHEMBL274012 | — | — | 1 | 7.20 |
| CHEMBL278889 | — | — | 1 | 7.15 |
| CHEMBL2370199 | — | — | 1 | 5.89 |
| CHEMBL2370207 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8234 | ENKEPHALIN | Ki | = | 2.53 | nM | 8.60 |
| CHEMBL557035 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL14887 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL15100 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL275670 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL278891 | — | Ki | = | 23.6 | nM | 7.63 |
| CHEMBL280264 | — | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL274012 | — | Ki | = | 62.6 | nM | 7.20 |
| CHEMBL278889 | — | Ki | = | 70.8 | nM | 7.15 |
| CHEMBL2370199 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL2370207 | — | Ki | = | 2140.0 | nM | 5.67 |