Assay Detail
Binding
CHEMBL758627
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Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4-kinase, PI4K (CHEMBL2096619) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 4.62 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293027 | — | — | 1 | 5.22 |
| CHEMBL63783 | — | — | 1 | 5.22 |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | 5.15 |
| CHEMBL62835 | — | — | 1 | 5.14 |
| CHEMBL413106 | — | — | 1 | 5.14 |
| CHEMBL294590 | — | — | 1 | 5.06 |
| CHEMBL306444 | — | — | 1 | 4.99 |
| CHEMBL1321883 | — | — | 1 | 4.92 |
| CHEMBL291377 | — | — | 1 | 4.92 |
| CHEMBL304265 | — | — | 1 | 4.89 |
| CHEMBL67199 | — | — | 1 | 4.83 |
| CHEMBL62756 | — | — | 1 | 4.81 |
| CHEMBL64565 | — | — | 1 | 4.79 |
| CHEMBL65063 | — | — | 1 | 4.79 |
| CHEMBL65685 | — | — | 1 | 4.79 |
| CHEMBL305102 | — | — | 1 | 4.66 |
| CHEMBL63815 | — | — | 1 | 4.64 |
| CHEMBL603180 | — | — | 1 | 4.64 |
| CHEMBL61397 | — | — | 1 | 4.63 |
| CHEMBL292498 | — | — | 1 | 4.59 |
| CHEMBL64239 | — | — | 1 | 4.55 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 4.52 |
| CHEMBL304009 | — | — | 1 | 4.49 |
| CHEMBL62648 | — | — | 1 | 4.48 |
| CHEMBL424597 | — | — | 1 | 4.46 |
| CHEMBL65379 | — | — | 1 | 4.39 |
| CHEMBL291843 | — | — | 1 | 4.34 |
| CHEMBL62757 | — | — | 1 | 4.33 |
| CHEMBL65276 | — | — | 1 | 4.31 |
| CHEMBL303125 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293027 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL63783 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL21619 | 2-AMINOPYRIDINE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL62835 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL413106 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL294590 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL306444 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL1321883 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL291377 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL304265 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL67199 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL62756 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL65685 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL65063 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL64565 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL305102 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL63815 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL603180 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL61397 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL292498 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL64239 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL477 | ADENOSINE | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL304009 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL62648 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL424597 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL65379 | — | IC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL291843 | — | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL62757 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL65276 | — | IC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL303125 | — | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL292541 | — | IC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL62828 | — | IC50 | = | 68900.0 | nM | 4.16 |
| CHEMBL65223 | — | IC50 | = | 75600.0 | nM | 4.12 |
| CHEMBL303563 | — | IC50 | = | 78800.0 | nM | 4.10 |
| CHEMBL65509 | — | IC50 | = | 82500.0 | nM | 4.08 |
| CHEMBL266094 | 9-BENZYL-9H-ADENINE | IC50 | = | 84400.0 | nM | 4.07 |
| CHEMBL266128 | 4-AMINOQUINAZOLINE | IC50 | = | 91700.0 | nM | 4.04 |
| CHEMBL388593 | — | IC50 | = | 144900.0 | nM | - |
| CHEMBL1788326 | — | IC50 | = | 215300.0 | nM | - |
| CHEMBL62647 | — | IC50 | = | 195400.0 | nM | - |
| CHEMBL293443 | — | IC50 | = | 116900.0 | nM | - |
| CHEMBL66077 | — | IC50 | = | 199500.0 | nM | - |
| CHEMBL62334 | — | IC50 | = | 134100.0 | nM | - |
| CHEMBL228862 | 6-BENZYLAMINOPURINE | IC50 | = | 240400.0 | nM | - |
| CHEMBL1788357 | — | IC50 | = | 146800.0 | nM | - |
| CHEMBL555400 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL65931 | — | IC50 | = | 126500.0 | nM | - |
| CHEMBL293629 | — | IC50 | = | 129800.0 | nM | - |
| CHEMBL65976 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | IC50 | = | 145300.0 | nM | - |