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Compound Detail

CHEMBL63783

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Nc1ncnc2c1ncn2C1CCCCC1

Basic Information

ChEMBL ID CHEMBL63783
Phase Preclinical
Structure Type MOL
InChI Key FRZBEYVOLNQETR-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

217.3
MW (Da)
1.91
ALogP
5
HBA
1
HBD
69.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H15N5
MW 217.28
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -0.25

Activity Summary

IC50 1 meas. best 5.22
Ki 1 meas. best 5.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phosphatidylinositol 4-kinase, PI4K
CHEMBL2096619
Ki 5.43 5.43 3700.0 1
Phosphatidylinositol 4-kinase, PI4K
CHEMBL2096619
IC50 5.22 5.22 6000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2165159 10.1021/jm00170a005 Phosphatidylinositol 4-kinase, PI4K 2
19731917 10.1021/jm9006356 Unchecked 2
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A1 1
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A2a 1
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A2b 1
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine