Assay Detail
Binding
CHEMBL758630
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Binding affinity (Ki) against human phosphatidylinositol 4-kinase
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4-kinase, PI4K (CHEMBL2096619) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 51 | 4.66 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63783 | — | — | 1 | 5.43 |
| CHEMBL293027 | — | — | 1 | 5.39 |
| CHEMBL62835 | — | — | 1 | 5.30 |
| CHEMBL413106 | — | — | 1 | 5.30 |
| CHEMBL294590 | — | — | 1 | 5.22 |
| CHEMBL306444 | — | — | 1 | 5.16 |
| CHEMBL1321883 | — | — | 1 | 5.08 |
| CHEMBL291377 | — | — | 1 | 5.08 |
| CHEMBL304265 | — | — | 1 | 5.05 |
| CHEMBL62756 | — | — | 1 | 4.99 |
| CHEMBL67199 | — | — | 1 | 4.99 |
| CHEMBL65685 | — | — | 1 | 4.96 |
| CHEMBL65063 | — | — | 1 | 4.96 |
| CHEMBL64565 | — | — | 1 | 4.96 |
| CHEMBL305102 | — | — | 1 | 4.82 |
| CHEMBL603180 | — | — | 1 | 4.80 |
| CHEMBL63815 | — | — | 1 | 4.80 |
| CHEMBL61397 | — | — | 1 | 4.78 |
| CHEMBL292498 | — | — | 1 | 4.75 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 4.72 |
| CHEMBL64239 | — | — | 1 | 4.67 |
| CHEMBL62648 | — | — | 1 | 4.64 |
| CHEMBL424597 | — | — | 1 | 4.62 |
| CHEMBL304009 | — | — | 1 | 4.59 |
| CHEMBL65379 | — | — | 1 | 4.55 |
| CHEMBL62757 | — | — | 1 | 4.50 |
| CHEMBL291843 | — | — | 1 | 4.50 |
| CHEMBL65276 | — | — | 1 | 4.47 |
| CHEMBL292541 | — | — | 1 | 4.45 |
| CHEMBL303125 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63783 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL293027 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL413106 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL62835 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL294590 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL306444 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL1321883 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL291377 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL304265 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL62756 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL67199 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL65685 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL65063 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL64565 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL305102 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL603180 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL63815 | — | Ki | = | 15800.0 | nM | 4.80 |
| CHEMBL61397 | — | Ki | = | 16500.0 | nM | 4.78 |
| CHEMBL292498 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL477 | ADENOSINE | Ki | = | 19200.0 | nM | 4.72 |
| CHEMBL64239 | — | Ki | = | 21200.0 | nM | 4.67 |
| CHEMBL62648 | — | Ki | = | 22700.0 | nM | 4.64 |
| CHEMBL424597 | — | Ki | = | 24100.0 | nM | 4.62 |
| CHEMBL304009 | — | Ki | = | 25500.0 | nM | 4.59 |
| CHEMBL65379 | — | Ki | = | 28200.0 | nM | 4.55 |
| CHEMBL62757 | — | Ki | = | 31800.0 | nM | 4.50 |
| CHEMBL291843 | — | Ki | = | 31700.0 | nM | 4.50 |
| CHEMBL65276 | — | Ki | = | 33600.0 | nM | 4.47 |
| CHEMBL292541 | — | Ki | = | 35800.0 | nM | 4.45 |
| CHEMBL303125 | — | Ki | = | 35800.0 | nM | 4.45 |
| CHEMBL62828 | — | Ki | = | 47500.0 | nM | 4.32 |
| CHEMBL65223 | — | Ki | = | 52300.0 | nM | 4.28 |
| CHEMBL303563 | — | Ki | = | 54400.0 | nM | 4.26 |
| CHEMBL65509 | — | Ki | = | 56800.0 | nM | 4.25 |
| CHEMBL266094 | 9-BENZYL-9H-ADENINE | Ki | = | 57900.0 | nM | 4.24 |
| CHEMBL266128 | 4-AMINOQUINAZOLINE | Ki | = | 63400.0 | nM | 4.20 |
| CHEMBL293443 | — | Ki | = | 80600.0 | nM | 4.09 |
| CHEMBL539503 | — | Ki | = | 85800.0 | nM | 4.07 |
| CHEMBL293629 | — | Ki | = | 89500.0 | nM | 4.05 |
| CHEMBL555400 | — | Ki | = | 91700.0 | nM | 4.04 |
| CHEMBL62334 | — | Ki | = | 93700.0 | nM | 4.03 |
| CHEMBL388593 | — | Ki | = | 99900.0 | nM | 4.00 |
| CHEMBL228862 | 6-BENZYLAMINOPURINE | Ki | = | 199000.0 | nM | - |
| CHEMBL66077 | — | Ki | = | 137700.0 | nM | - |
| CHEMBL1788326 | — | Ki | = | 148400.0 | nM | - |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | Ki | = | 100100.0 | nM | - |
| CHEMBL65976 | — | Ki | = | 110900.0 | nM | - |
| CHEMBL1788357 | — | Ki | = | 101200.0 | nM | - |
| CHEMBL407391 | DIMETHYLADENINE | Ki | = | 150200.0 | nM | - |
| CHEMBL62647 | — | Ki | = | 134300.0 | nM | - |