Compound Detail
CHEMBL266128
4-AMINOQUINAZOLINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL266128 |
| Name | 4-AMINOQUINAZOLINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DRYRBWIFRVMRPV-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
145.2
MW (Da)
1.21
ALogP
3
HBA
1
HBD
51.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.04
Ki 1 meas. best 4.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-kinase, PI4K CHEMBL2096619 | Ki | 4.2 | 4.2 | 63400.0 | 1 |
| Phosphatidylinositol 4-kinase, PI4K CHEMBL2096619 | IC50 | 4.04 | 4.04 | 91700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4-kinase, PI4K | Ki | = | 63400.0 | nM | 4.2 | Binding affinity (Ki) against human phosphatidylinositol 4-kinase | 2165159 |
| Phosphatidylinositol 4-kinase, PI4K | IC50 | = | 91700.0 | nM | 4.04 | Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the AT... | 2165159 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2404122 | 10.1021/jm00163a067 | Mus musculus | 2 |
| 2165159 | 10.1021/jm00170a005 | Phosphatidylinositol 4-kinase, PI4K | 2 |
| 6864738 | 10.1021/jm00361a012 | Dihydrofolate reductase | 1 |
| 21145740 | 10.1016/j.bmcl.2010.11.060 | Rho-associated protein kinase 1 | 1 |
| 1271401 | 10.1021/jm00227a006 | Dihydrofolate reductase | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine