Assay Detail
Functional
CHEMBL760408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of P388 (murine leukemia) cell growth.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.71 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068463 | Dichloro(1,3-propanediamine)platinum (II) | — | 1 | 6.92 |
| CHEMBL101124 | — | — | 1 | 6.92 |
| CHEMBL367622 | DICHLORO(ETHYLENEDIAMINE) PLATINUM (II) | — | 1 | 6.52 |
| CHEMBL100901 | — | — | 1 | 6.51 |
| CHEMBL329726 | — | — | 1 | 6.14 |
| CHEMBL318627 | — | — | 1 | 6.14 |
| CHEMBL2068460 | Platinum complex | — | 1 | 5.92 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.92 |
| CHEMBL2068321 | Platinum complex | — | 1 | 5.82 |
| CHEMBL2068456 | 9-[4-(5-Amino-4-aminomethyl-pentyl)-phenylamino]-5-methoxy-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (2HCl) | — | 1 | 5.80 |
| CHEMBL2068464 | Platinum complex | — | 1 | 5.75 |
| CHEMBL2068320 | 2-{3-[4-(Acridin-9-ylamino)-phenyl]-propyl}-propane-1,3-diammino-dichloroplatinum (II) (HCl) | — | 1 | 5.54 |
| CHEMBL2068555 | N,1-{2-[4-(Acridin-9-ylamino)-phenyl]-ethyl}-ethane-1,2-diammino-dichloroplatinum (II) | — | 1 | 5.54 |
| CHEMBL99676 | — | — | 1 | 5.43 |
| CHEMBL2068325 | Platinum complex | — | 1 | 5.43 |
| CHEMBL2068322 | Platinum complex | — | 1 | 5.21 |
| CHEMBL2068324 | 2-{4-[4-(Acridin-9-ylamino)-phenyl]-butyl}-propane-1,3-diammino-dichloroplatinum (II) (HCl) | — | 1 | 5.14 |
| CHEMBL102745 | — | — | 1 | 5.14 |
| CHEMBL102309 | — | — | 1 | 5.14 |
| CHEMBL102746 | — | — | 1 | 5.11 |
| CHEMBL89150 | — | — | 1 | 4.90 |
| CHEMBL2068457 | Platinum complex | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068463 | Dichloro(1,3-propanediamine)platinum (II) | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL101124 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL367622 | DICHLORO(ETHYLENEDIAMINE) PLATINUM (II) | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL100901 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL329726 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL318627 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2068460 | Platinum complex | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2068321 | Platinum complex | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2068456 | 9-[4-(5-Amino-4-aminomethyl-pentyl)-phenylamino]-5-methoxy-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (2HCl) | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2068464 | Platinum complex | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2068320 | 2-{3-[4-(Acridin-9-ylamino)-phenyl]-propyl}-propane-1,3-diammino-dichloroplatinum (II) (HCl) | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2068555 | N,1-{2-[4-(Acridin-9-ylamino)-phenyl]-ethyl}-ethane-1,2-diammino-dichloroplatinum (II) | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL99676 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2068325 | Platinum complex | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2068322 | Platinum complex | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2068324 | 2-{4-[4-(Acridin-9-ylamino)-phenyl]-butyl}-propane-1,3-diammino-dichloroplatinum (II) (HCl) | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL102745 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL102309 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL102746 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL89150 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2068457 | Platinum complex | IC50 | = | 20000.0 | nM | 4.70 |