Assay Detail
Binding
CHEMBL760875
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Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ScN2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.47 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 6.52 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 5.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.40 |
| CHEMBL39560 | ACEPROMAZINE | 2.0 | 1 | 5.30 |
| CHEMBL564 | PROMAZINE | 4.0 | 1 | 5.30 |
| CHEMBL643 | PROMETHAZINE | 4.0 | 1 | 5.10 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 5.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | - |
| CHEMBL119870 | PHENAZINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7568 | QUINACRINE | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL71 | CHLORPROMAZINE | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL39560 | ACEPROMAZINE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL564 | PROMAZINE | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL643 | PROMETHAZINE | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL11 | IMIPRAMINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL54 | HALOPERIDOL | EC50 | > | 10000.0 | nM | - |
| CHEMBL108 | CARBAMAZEPINE | EC50 | > | 10000.0 | nM | - |
| CHEMBL119870 | PHENAZINE | EC50 | > | 10000.0 | nM | - |