Assay Detail
Binding
CHEMBL767890
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Inhibitory concentration against recombinant human Protein kinase C gamma isozyme
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and protein kinase C inhibitory activities of balanol analogs with replacement of the perhydroazepine moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.99 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432168 | — | — | 1 | 8.30 |
| CHEMBL75661 | — | — | 1 | 8.30 |
| CHEMBL307708 | — | — | 1 | 8.30 |
| CHEMBL308263 | — | — | 1 | 8.00 |
| CHEMBL52529 | — | — | 1 | 8.00 |
| CHEMBL59828 | — | — | 1 | 7.89 |
| CHEMBL306580 | — | — | 1 | 7.70 |
| CHEMBL60254 | BALANOL | — | 1 | 7.70 |
| CHEMBL49354 | — | — | 1 | 7.52 |
| CHEMBL309034 | — | — | 1 | 7.52 |
| CHEMBL80525 | — | — | 1 | 7.40 |
| CHEMBL75004 | — | — | 1 | 7.30 |
| CHEMBL263910 | — | — | 1 | 7.30 |
| CHEMBL304549 | — | — | 1 | 7.22 |
| CHEMBL76920 | — | — | 1 | 7.05 |
| CHEMBL78129 | — | — | 1 | 6.85 |
| CHEMBL309078 | — | — | 1 | 6.68 |
| CHEMBL262980 | — | — | 1 | 6.58 |
| CHEMBL441802 | — | — | 1 | 6.41 |
| CHEMBL77970 | — | — | 1 | 6.40 |
| CHEMBL306623 | — | — | 1 | 6.40 |
| CHEMBL312067 | — | — | 1 | 6.39 |
| CHEMBL77399 | — | — | 1 | 6.27 |
| CHEMBL76537 | — | — | 1 | 6.00 |
| CHEMBL306373 | — | — | 1 | 6.00 |
| CHEMBL67442 | — | — | 1 | 5.66 |
| CHEMBL305718 | — | — | 1 | 5.37 |
| CHEMBL306883 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432168 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL75661 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL307708 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL308263 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL52529 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59828 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL306580 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL60254 | BALANOL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL49354 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL309034 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL80525 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL75004 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL263910 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL304549 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL76920 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL78129 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL309078 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL262980 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL441802 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL77970 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL306623 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL312067 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL77399 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL76537 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL306373 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL67442 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL305718 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL306883 | — | IC50 | = | 4600.0 | nM | 5.34 |