Assay Detail
Functional
CHEMBL768980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.74 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334275 | — | — | 1 | 9.30 |
| CHEMBL324709 | — | — | 1 | 9.30 |
| CHEMBL119412 | — | — | 1 | 9.30 |
| CHEMBL434028 | — | — | 1 | 9.22 |
| CHEMBL331566 | — | — | 1 | 9.15 |
| CHEMBL115529 | — | — | 1 | 9.05 |
| CHEMBL119366 | — | — | 1 | 8.72 |
| CHEMBL116198 | — | — | 1 | 8.40 |
| CHEMBL29067 | — | — | 1 | 8.37 |
| CHEMBL119847 | — | — | 1 | 8.31 |
| CHEMBL333674 | — | — | 1 | 8.30 |
| CHEMBL116515 | — | — | 1 | 7.82 |
| CHEMBL118017 | — | — | 1 | 7.36 |
| CHEMBL119470 | — | — | 1 | 7.17 |
| CHEMBL325439 | BEPAFANT | 2.0 | 1 | 7.14 |
| CHEMBL273392 | — | — | 1 | 6.72 |
| CHEMBL326077 | — | — | 1 | 6.70 |
| CHEMBL115695 | — | — | 1 | 6.46 |
| CHEMBL333242 | — | — | 1 | 6.22 |
| CHEMBL323940 | — | — | 1 | 6.08 |
| CHEMBL326517 | — | — | 1 | 5.58 |
| CHEMBL117250 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334275 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL324709 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL119412 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL434028 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL331566 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL115529 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL119366 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL116198 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL29067 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL119847 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL333674 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL116515 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL118017 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL119470 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL325439 | BEPAFANT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL273392 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL326077 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL115695 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL333242 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL323940 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL326517 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL117250 | — | IC50 | = | 2800.0 | nM | 5.55 |