Compound Detail
CHEMBL325439
BEPAFANT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL325439 |
| Name | BEPAFANT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FWYVRZOREBYLCY-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
20
Publications
2
Known Names
Molecular Properties
468.0
MW (Da)
3.22
ALogP
7
HBA
0
HBD
72.6
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 2 meas. best 7.14
Ki 1 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL5136 | Ki | 7.54 | 7.54 | 29.2 | 1 |
| Platelet-activating factor receptor CHEMBL5136 | IC50 | 7.14 | 7.14 | 73.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | Ki | = | 29.2 | nM | 7.54 | Antagonist activity against platelet activating factor (PAF) receptor in rabbit ... | 8027984 |
| Platelet-activating factor receptor | IC50 | = | 73.0 | nM | 7.14 | In vitro antagonist activity against platelet activating factor (PAF) receptor, ... | 7658439 |
| Platelet-activating factor receptor | IC50 | = | 73.0 | nM | 7.14 | Antagonistic activity was tested against Platelet-Activating Factor-induced aggr... | 7658438 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5303304 | Fibroblast | 12 |
| - | 10.6019/CHEMBL5303304 | U2OS | 4 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 3 |
| 7658439 | 10.1021/jm00018a012 | Platelet-activating factor receptor | 2 |
| - | 10.6019/CHEMBL5308504 | Casein kinase I isoform delta | 1 |
| - | 10.6019/CHEMBL5308504 | Bromodomain-containing protein 4 | 1 |
| - | 10.6019/CHEMBL5308504 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5308504 | Peregrin | 1 |
| - | 10.6019/CHEMBL5308504 | Fibroblast growth factor receptor 3 | 1 |
| - | 10.6019/CHEMBL5308504 | Tyrosine-protein kinase ABL1 | 1 |
| - | 10.6019/CHEMBL5308504 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5308504 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5308504 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5308504 | Cyclin-dependent kinase 2 | 1 |
| 8027984 | 10.1021/jm00039a015 | Rattus norvegicus | 1 |
| 8027984 | 10.1021/jm00039a015 | Mus musculus | 1 |
| 8027984 | 10.1021/jm00039a015 | Platelet-activating factor receptor | 1 |
| 7658438 | 10.1021/jm00018a011 | Mus musculus | 1 |
| 7658438 | 10.1021/jm00018a011 | Platelet-activating factor receptor | 1 |
| 7658439 | 10.1021/jm00018a012 | Canis familiaris | 1 |
Data from ChEMBL 36 via Core Engine