Assay Detail
Functional
CHEMBL769495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit PAF-induced maximum platelet aggregation in rabbit platelet-rich plasma
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.60 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322832 | LEXIPAFANT | 2.0 | 1 | 8.44 |
| CHEMBL147154 | — | — | 1 | 8.21 |
| CHEMBL341648 | — | — | 1 | 8.17 |
| CHEMBL341855 | — | — | 1 | 8.16 |
| CHEMBL101374 | — | — | 1 | 8.12 |
| CHEMBL148101 | — | — | 1 | 8.09 |
| CHEMBL147883 | — | — | 1 | 7.96 |
| CHEMBL148206 | — | — | 1 | 7.92 |
| CHEMBL145965 | — | — | 1 | 7.92 |
| CHEMBL146776 | — | — | 1 | 7.92 |
| CHEMBL144663 | — | — | 1 | 7.92 |
| CHEMBL144697 | — | — | 1 | 7.89 |
| CHEMBL147674 | — | — | 1 | 7.89 |
| CHEMBL146019 | — | — | 1 | 7.89 |
| CHEMBL147320 | — | — | 1 | 7.85 |
| CHEMBL146878 | — | — | 1 | 7.82 |
| CHEMBL147951 | — | — | 1 | 7.80 |
| CHEMBL147750 | — | — | 1 | 7.77 |
| CHEMBL143838 | — | — | 1 | 7.77 |
| CHEMBL344712 | — | — | 1 | 7.75 |
| CHEMBL341865 | — | — | 1 | 7.64 |
| CHEMBL134123 | — | — | 1 | 7.62 |
| CHEMBL147723 | — | — | 1 | 7.46 |
| CHEMBL144050 | — | — | 1 | 7.44 |
| CHEMBL100493 | — | — | 1 | 7.40 |
| CHEMBL343660 | — | — | 1 | 7.39 |
| CHEMBL418792 | — | — | 1 | 7.39 |
| CHEMBL147104 | — | — | 1 | 7.22 |
| CHEMBL280164 | APAFANT | 2.0 | 1 | 7.04 |
| CHEMBL174552 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322832 | LEXIPAFANT | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL147154 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL341648 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL341855 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL101374 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL148101 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL147883 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL148206 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL145965 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL146776 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144663 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144697 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147674 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL146019 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147320 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL146878 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL147951 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL147750 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL143838 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL344712 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL341865 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL134123 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL147723 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL144050 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL100493 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL343660 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL418792 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL147104 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL280164 | APAFANT | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL174552 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL143839 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL147103 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL147626 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL356097 | — | IC50 | = | 1300.0 | nM | 5.89 |