Compound Detail
CHEMBL101374
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Basic Information
| ChEMBL ID | CHEMBL101374 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HXCOKIFMWJDWPX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
438.6
MW (Da)
5.20
ALogP
4
HBA
0
HBD
51.0
PSA (Ų)
0.42
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oryctolagus cuniculus CHEMBL374 | IC50 | 8.12 | 8.12 | 7.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | IC50 | = | 7.6 | nM | 8.12 | Concentration required to inhibit PAF-induced maximum aggregation by 50% | 11520209 |
| Oryctolagus cuniculus | IC50 | = | 7.6 | nM | 8.12 | Concentration required to inhibit PAF-induced maximum platelet aggregation in ra... | 8558517 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8558517 | 10.1021/jm950555i | Mus musculus | 5 |
| 8558517 | 10.1021/jm950555i | Canis familiaris | 2 |
| 11520209 | 10.1021/jm010852p | Oryctolagus cuniculus | 1 |
| 11520209 | 10.1021/jm010852p | Rattus norvegicus | 1 |
| 8558517 | 10.1021/jm950555i | Oryctolagus cuniculus | 1 |
| 8558517 | 10.1021/jm950555i | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine