Assay Detail
Functional
CHEMBL772476
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Concentration required to inhibit PAF-induced maximum aggregation by 50%
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.77 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322832 | LEXIPAFANT | 2.0 | 1 | 8.44 |
| CHEMBL101379 | — | — | 1 | 8.30 |
| CHEMBL101374 | — | — | 1 | 8.12 |
| CHEMBL100535 | — | — | 1 | 8.10 |
| CHEMBL103250 | — | — | 1 | 7.96 |
| CHEMBL103295 | — | — | 1 | 7.92 |
| CHEMBL103210 | — | — | 1 | 7.80 |
| CHEMBL329935 | — | — | 1 | 7.77 |
| CHEMBL321064 | — | — | 1 | 7.72 |
| CHEMBL101198 | — | — | 1 | 7.54 |
| CHEMBL321501 | — | — | 1 | 7.52 |
| CHEMBL323063 | — | — | 1 | 7.50 |
| CHEMBL320862 | — | — | 1 | 7.22 |
| CHEMBL102287 | — | — | 1 | 7.13 |
| CHEMBL103728 | — | — | 1 | 7.12 |
| CHEMBL280164 | APAFANT | 2.0 | 1 | 7.04 |
| CHEMBL101241 | — | — | 1 | 6.92 |
| CHEMBL323522 | — | — | 1 | 6.72 |
| CHEMBL100494 | — | — | 1 | 6.60 |
| CHEMBL103888 | — | — | 1 | 6.60 |
| CHEMBL103071 | — | — | 1 | 6.57 |
| CHEMBL101746 | — | — | 1 | 6.52 |
| CHEMBL265100 | — | — | 1 | 6.40 |
| CHEMBL103037 | — | — | 1 | 6.37 |
| CHEMBL102845 | — | — | 1 | 6.31 |
| CHEMBL103727 | — | — | 1 | 6.21 |
| CHEMBL274760 | — | — | 1 | 6.13 |
| CHEMBL105192 | — | — | 1 | 5.92 |
| CHEMBL102648 | — | — | 1 | 5.90 |
| CHEMBL103257 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322832 | LEXIPAFANT | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL101379 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL101374 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL100535 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL103250 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL103295 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL103210 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL329935 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL321064 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL101198 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL321501 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL323063 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL320862 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL102287 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL103728 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL280164 | APAFANT | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL101241 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL323522 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL100494 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL103888 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL103071 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL101746 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL265100 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL103037 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL102845 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL103727 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL274760 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL105192 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL102648 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL103257 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL101689 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL100450 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL450937 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL102561 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL105848 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL102621 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL102620 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL319691 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1201346 | BALSALAZIDE | IC50 | > | 200000.0 | nM | - |
| CHEMBL421 | SULFASALAZINE | IC50 | > | 200000.0 | nM | - |