Assay Detail
Functional
CHEMBL770471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF-stimulated Platelet-derived growth factor receptor autophosphorylation in rat aorta vascular smooth muscle cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor (PDGFr) (CHEMBL2111344) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.15 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80873 | — | — | 1 | 6.89 |
| CHEMBL153054 | — | — | 1 | 6.82 |
| CHEMBL76202 | — | — | 1 | 5.72 |
| CHEMBL346870 | — | — | 1 | 5.70 |
| CHEMBL310080 | — | — | 1 | 5.64 |
| CHEMBL75964 | — | — | 1 | - |
| CHEMBL356169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80873 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL153054 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL76202 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL346870 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL310080 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL75964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL356169 | — | IC50 | > | 10000.0 | nM | - |