Compound Detail
CHEMBL346870
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Basic Information
| ChEMBL ID | CHEMBL346870 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DWYMPMWWYZEKLQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
209.2
MW (Da)
2.61
ALogP
3
HBA
1
HBD
43.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor (PDGFr) CHEMBL2111344 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 5.25 | 5.25 | 5600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor (PDGFr) | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of PDGF-stimulated Platelet-derived growth factor receptor autophosph... | 9876115 |
| Platelet-derived growth factor receptor beta | IC50 | = | 5600.0 | nM | 5.25 | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysate... | 9876115 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9876115 | 10.1021/jm9804681 | Platelet-derived growth factor receptor beta | 1 |
| 9876115 | 10.1021/jm9804681 | Fibroblast growth factor receptor 1 | 1 |
| 9876115 | 10.1021/jm9804681 | Platelet-derived growth factor receptor (PDGFr) | 1 |
Data from ChEMBL 36 via Core Engine