Compound Detail
CHEMBL356169
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Basic Information
| ChEMBL ID | CHEMBL356169 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DBDPQMUWFPDEFP-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
224.3
MW (Da)
3.03
ALogP
3
HBA
0
HBD
27.1
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nuclear receptor coactivator 3 CHEMBL1615382 | IC50 | 5.52 | 5.52 | 2991.0 | 1 |
| Tegument protein VP16 CHEMBL4218 | IC50 | 5.23 | 5.23 | 5946.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 5.19 | 5.19 | 6400.0 | 1 |
| Nuclear receptor coactivator 1 CHEMBL1615387 | IC50 | 5.09 | 5.09 | 8162.0 | 1 |
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 4.46 | 4.46 | 34880.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nuclear receptor coactivator 3 | IC50 | = | 2991.0 | nM | 5.52 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the Steroid Receptor Coactivat... | - |
| Tegument protein VP16 | IC50 | = | 5946.0 | nM | 5.23 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of the Steroid Receptor Coactivat... | - |
| Platelet-derived growth factor receptor beta | IC50 | = | 6400.0 | nM | 5.19 | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysate... | 9876115 |
| Nuclear receptor coactivator 1 | IC50 | = | 8162.0 | nM | 5.09 | PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response as... | - |
| Mitogen-activated protein kinase 10 | IC50 | = | 34880.0 | nM | 4.46 | PUBCHEM_BIOASSAY: Dose response biochemical screening assay for inhibitors of c-... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9876115 | 10.1021/jm9804681 | Platelet-derived growth factor receptor beta | 1 |
| 9876115 | 10.1021/jm9804681 | Fibroblast growth factor receptor 1 | 1 |
| 9876115 | 10.1021/jm9804681 | Platelet-derived growth factor receptor (PDGFr) | 1 |
Data from ChEMBL 36 via Core Engine