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Assay Detail

CHEMBL770809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity pA2, was measured in the in vitro rabbit aorta strip assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Aorta
Confidence 1 — Organism
Curated By Expert

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

The role of position 4 in angiotensin II antagonism: a structure-activity study.
Samanen J, Cash T, Narindray D, Brandeis E, Yellin T, Regoli D.
J Med Chem (1989) 32 : 1366 -1370
PubMed 2724307 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 27 7.67 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404594 1 9.10
CHEMBL2364552 1 9.00
CHEMBL3247163 1 8.78
CHEMBL312754 1 8.61
CHEMBL3350601 1 8.50
CHEMBL2392353 ANGIOTENSIN-II 1 8.32
CHEMBL2112883 1 8.25
CHEMBL3350969 1 8.09
CHEMBL3350658 1 7.90
CHEMBL3350964 1 7.50
CHEMBL2311145 1 7.50
CHEMBL3350963 1 7.50
CHEMBL2371021 1 7.10
CHEMBL2371453 1 7.10
CHEMBL3350594 1 7.10
CHEMBL428822 1 7.00
CHEMBL3350690 1 6.85
CHEMBL3350597 1 6.80
CHEMBL3350962 1 6.60
CHEMBL3350595 1 5.70
CHEMBL3350598 1 -
CHEMBL3350961 1 -
CHEMBL3351042 1 -
CHEMBL3350593 1 -
CHEMBL3350960 1 -
CHEMBL3350966 1 -
CHEMBL216061 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404594 Kd = 0.7943 nM 9.10
CHEMBL2364552 Kd = 1.0 nM 9.00
CHEMBL3247163 Kd = 1.66 nM 8.78
CHEMBL312754 Kd = 2.455 nM 8.61
CHEMBL3350601 Kd = 3.162 nM 8.50
CHEMBL2392353 ANGIOTENSIN-II Kd = 4.786 nM 8.32
CHEMBL2112883 Kd = 5.623 nM 8.25
CHEMBL3350969 Kd = 8.128 nM 8.09
CHEMBL3350658 Kd = 12.59 nM 7.90
CHEMBL3350964 Kd = 31.62 nM 7.50
CHEMBL2311145 Kd = 31.62 nM 7.50
CHEMBL3350963 Kd = 31.62 nM 7.50
CHEMBL2371021 Kd = 79.43 nM 7.10
CHEMBL2371453 Kd = 79.43 nM 7.10
CHEMBL3350594 Kd = 79.43 nM 7.10
CHEMBL428822 Kd = 100.0 nM 7.00
CHEMBL3350690 Kd = 141.25 nM 6.85
CHEMBL3350597 Kd = 158.49 nM 6.80
CHEMBL3350962 Kd = 251.19 nM 6.60
CHEMBL3350595 Kd = 1995.26 nM 5.70
CHEMBL3350598 Kd > 1000.0 nM -
CHEMBL3350961 Kd = 1000000000.0 nM -
CHEMBL3351042 Kd << 6.0 nM -
CHEMBL3350593 Kd > 1000.0 nM -
CHEMBL3350960 Kd = 1000000000.0 nM -
CHEMBL3350966 Kd << 6.0 nM -
CHEMBL216061 Kd = 1000000000.0 nM -