Compound Detail
CHEMBL428822
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL428822 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | HFMFHCLRTZLTNN-IXVZVOFNSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
1002.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin II receptor CHEMBL2094256 | Kd | 7.0 | 7.0 | 100.0 | 1 |
| Oryctolagus cuniculus CHEMBL374 | Kd | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | Kd | = | 100.0 | nM | 7.0 | Antagonist activity pA2, was measured in the in vitro rabbit aorta strip assay | 2724307 |
| Angiotensin II receptor | Kd | = | 100.0 | nM | 7.0 | pA2 value was determined in the range of competitive inhibition in the in vitro ... | 3346871 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2724307 | 10.1021/jm00126a037 | Angiotensin II receptor | 2 |
| 3346871 | 10.1021/jm00398a005 | Angiotensin II receptor | 2 |
| 3346871 | 10.1021/jm00398a005 | Rattus norvegicus | 2 |
| 2724307 | 10.1021/jm00126a037 | Oryctolagus cuniculus | 1 |
| 2724307 | 10.1021/jm00126a037 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine