Assay Detail
Binding
CHEMBL770866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency to displace the specific in vitro binding of [3H]DP-5,6-ADTN to rat striatal membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.05 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69271 | NAXAGOLIDE | 2.0 | 1 | 8.52 |
| CHEMBL38428 | — | — | 1 | 8.40 |
| CHEMBL285755 | — | — | 1 | 7.52 |
| CHEMBL607437 | — | — | 1 | 7.12 |
| CHEMBL69414 | — | — | 1 | 6.75 |
| CHEMBL607438 | — | — | 1 | 5.53 |
| CHEMBL70565 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69271 | NAXAGOLIDE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL38428 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL285755 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL607437 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL69414 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL607438 | — | IC50 | = | 2923.0 | nM | 5.53 |
| CHEMBL70565 | — | IC50 | = | 3070.0 | nM | 5.51 |