Assay Detail
Functional
CHEMBL771383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration which produces 50% of maximal contractile response at rabbit aorta strips
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological activities of four angiotensin II receptor ligands with gamma-turn mimetics replacing amino acid residues 3-5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.11 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | 4.0 | 1 | 8.59 |
| CHEMBL413740 | — | — | 1 | 6.66 |
| CHEMBL1791267 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408403 | ANGIOTENSIN II | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL413740 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL1791267 | — | EC50 | = | 830.0 | nM | 6.08 |