Assay Detail
Functional
CHEMBL771605
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In vitro evaluation for the vasorelaxant effects in circumferential strips of potassium-depolarized rabbit aorta. (IC50 in rabbit aorta strips contracted with KCl)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Benzazepinone calcium channel blockers. 3. Synthesis and structure-activity studies of 3-alkylbenzazepinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.69 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204379 | — | — | 1 | 7.92 |
| CHEMBL164515 | — | — | 1 | 7.77 |
| CHEMBL1203799 | — | — | 1 | 7.16 |
| CHEMBL1204374 | — | — | 1 | 7.11 |
| CHEMBL350273 | — | — | 1 | 7.10 |
| CHEMBL167935 | — | — | 1 | 7.10 |
| CHEMBL1204375 | — | — | 1 | 7.05 |
| CHEMBL348763 | CLENTIAZEM | 2.0 | 1 | 7.00 |
| CHEMBL2093048 | — | — | 1 | 7.00 |
| CHEMBL168068 | — | — | 1 | 6.82 |
| CHEMBL433409 | — | — | 1 | 6.82 |
| CHEMBL164658 | — | — | 1 | 6.80 |
| CHEMBL1204378 | — | — | 1 | 6.72 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.68 |
| CHEMBL1203798 | — | — | 1 | 6.62 |
| CHEMBL348847 | — | — | 1 | 6.55 |
| CHEMBL1204377 | — | — | 1 | 6.47 |
| CHEMBL1204376 | — | — | 1 | 6.38 |
| CHEMBL163839 | — | — | 1 | 6.10 |
| CHEMBL1204373 | — | — | 1 | 6.02 |
| CHEMBL1204308 | — | — | 1 | 5.96 |
| CHEMBL1203797 | — | — | 1 | 5.92 |
| CHEMBL1203795 | — | — | 1 | 5.91 |
| CHEMBL1203796 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204379 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL164515 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1203799 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1204374 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL350273 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL167935 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1204375 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL348763 | CLENTIAZEM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2093048 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL168068 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL433409 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL164658 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1204378 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1203798 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL348847 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1204377 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1204376 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL163839 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1204373 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1204308 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1203797 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1203795 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1203796 | — | IC50 | = | 3290.0 | nM | 5.48 |