Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL772964

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro concentration that reduced U-44069-induced contraction of the rabbit aorta by 50%
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Aorta
Confidence 1 — Organism
Curated By Expert

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation.
Shiraishi M, Kato K, Terao S, Ashida Y, Terashita Z, Kito G.
J Med Chem (1989) 32 : 2214 -2221
PubMed 2769691 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.03 7.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71222 1 7.32
CHEMBL70972 SERATRODAST 4.0 1 7.00
CHEMBL68308 1 6.62
CHEMBL72648 1 6.55
CHEMBL73397 1 6.12
CHEMBL306545 1 6.00
CHEMBL70992 1 5.85
CHEMBL72263 1 5.77
CHEMBL306042 1 5.72
CHEMBL70836 1 5.52
CHEMBL74353 1 5.50
CHEMBL69199 1 5.50
CHEMBL71336 1 5.50
CHEMBL71187 1 5.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71222 IC50 = 48.0 nM 7.32
CHEMBL70972 SERATRODAST IC50 = 100.0 nM 7.00
CHEMBL68308 IC50 = 240.0 nM 6.62
CHEMBL72648 IC50 = 280.0 nM 6.55
CHEMBL73397 IC50 = 760.0 nM 6.12
CHEMBL306545 IC50 = 1000.0 nM 6.00
CHEMBL70992 IC50 = 1400.0 nM 5.85
CHEMBL72263 IC50 = 1700.0 nM 5.77
CHEMBL306042 IC50 = 1900.0 nM 5.72
CHEMBL70836 IC50 = 3000.0 nM 5.52
CHEMBL74353 IC50 = 3200.0 nM 5.50
CHEMBL69199 IC50 = 3200.0 nM 5.50
CHEMBL71336 IC50 = 3200.0 nM 5.50
CHEMBL71187 IC50 = 3400.0 nM 5.47