Assay Detail
Functional
CHEMBL773449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the in vitro smooth muscle contractile activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Macrolide-type motilin receptor agonists: Acid-stable 12-O-methyl-8,9-anhydroerythromycin A 6,9-hemiacetals
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.59 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351216 | — | — | 1 | 7.89 |
| CHEMBL166642 | — | — | 1 | 7.71 |
| CHEMBL262052 | — | — | 1 | 7.64 |
| CHEMBL300004 | — | — | 1 | 7.38 |
| CHEMBL353526 | — | — | 1 | 7.32 |
| CHEMBL281952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351216 | — | EC50 | = | 12.88 | nM | 7.89 |
| CHEMBL166642 | — | EC50 | = | 19.5 | nM | 7.71 |
| CHEMBL262052 | — | EC50 | = | 22.91 | nM | 7.64 |
| CHEMBL300004 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL353526 | — | EC50 | = | 47.86 | nM | 7.32 |
| CHEMBL281952 | — | EC50 | < | 10000.0 | nM | - |