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Assay Detail

CHEMBL781943

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Functional
Inhibition of noradrenaline uptake in rat synaptosomal fraction
ChEMBL ↗
68
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Norepinephrine transporter (CHEMBL304) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.
Bøgesø KP, Christensen AV, Hyttel J, Liljefors T.
J Med Chem (1985) 28 : 1817 -1828
PubMed 2999402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 7.93 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL544500 — — 2 9.92
CHEMBL544266 — — 2 9.59
CHEMBL545671 — — 2 9.52
CHEMBL545201 — — 2 9.49
CHEMBL51224 — — 1 9.29
CHEMBL555549 — — 2 9.25
CHEMBL296602 INDATRALINE 2.0 2 9.22
CHEMBL553590 — — 1 9.18
CHEMBL300019 — — 1 9.17
CHEMBL544971 — — 2 9.15
CHEMBL543324 — — 2 9.11
CHEMBL52247 TALSUPRAM 2.0 1 9.10
CHEMBL301514 — — 2 9.09
CHEMBL542850 — — 2 8.80
CHEMBL552891 — — 1 8.62
CHEMBL54177 — — 6 8.60
CHEMBL542121 — — 2 8.54
CHEMBL299233 TALOPRAM 2.0 1 8.54
CHEMBL53837 — — 2 8.52
CHEMBL553385 — — 2 8.43
CHEMBL300069 — — 2 8.37
CHEMBL50635 — — 2 8.36
CHEMBL542117 — — 2 8.21
CHEMBL273575 NOMIFENSINE 4.0 1 8.18
CHEMBL53635 — — 1 7.80
CHEMBL537996 — — 1 7.72
CHEMBL301782 — — 1 7.62
CHEMBL554756 — — 1 7.62
CHEMBL554433 — — 2 7.62
CHEMBL554610 — — 1 7.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL544500 — IC50 = 0.12 nM 9.92
CHEMBL544266 — IC50 = 0.26 nM 9.59
CHEMBL545671 — IC50 = 0.3 nM 9.52
CHEMBL545201 — IC50 = 0.32 nM 9.49
CHEMBL51224 — IC50 = 0.51 nM 9.29
CHEMBL555549 — IC50 = 0.56 nM 9.25
CHEMBL296602 INDATRALINE IC50 = 0.6 nM 9.22
CHEMBL553590 — IC50 = 0.66 nM 9.18
CHEMBL300019 — IC50 = 0.67 nM 9.17
CHEMBL544971 — IC50 = 0.71 nM 9.15
CHEMBL543324 — IC50 = 0.77 nM 9.11
CHEMBL52247 TALSUPRAM IC50 = 0.79 nM 9.10
CHEMBL301514 — IC50 = 0.82 nM 9.09
CHEMBL542850 — IC50 = 1.6 nM 8.80
CHEMBL552891 — IC50 = 2.4 nM 8.62
CHEMBL54177 — IC50 = 2.5 nM 8.60
CHEMBL542121 — IC50 = 2.9 nM 8.54
CHEMBL299233 TALOPRAM IC50 = 2.9 nM 8.54
CHEMBL53837 — IC50 = 3.0 nM 8.52
CHEMBL553385 — IC50 = 3.7 nM 8.43
CHEMBL300069 — IC50 = 4.3 nM 8.37
CHEMBL50635 — IC50 = 4.4 nM 8.36
CHEMBL296602 INDATRALINE IC50 = 5.3 nM 8.28
CHEMBL544266 — IC50 = 5.2 nM 8.28
CHEMBL542117 — IC50 = 6.1 nM 8.21
CHEMBL301514 — IC50 = 6.3 nM 8.20
CHEMBL273575 NOMIFENSINE IC50 = 6.6 nM 8.18
CHEMBL54177 — IC50 = 7.8 nM 8.11
CHEMBL54177 — IC50 = 7.7 nM 8.11
CHEMBL545671 — IC50 = 8.8 nM 8.06
CHEMBL555549 — IC50 = 13.0 nM 7.89
CHEMBL544971 — IC50 = 14.0 nM 7.85
CHEMBL542117 — IC50 = 15.0 nM 7.82
CHEMBL543324 — IC50 = 15.0 nM 7.82
CHEMBL53635 — IC50 = 16.0 nM 7.80
CHEMBL53837 — IC50 = 16.0 nM 7.80
CHEMBL537996 — IC50 = 19.0 nM 7.72
CHEMBL544500 — IC50 = 19.0 nM 7.72
CHEMBL553385 — IC50 = 21.0 nM 7.68
CHEMBL50635 — IC50 = 23.0 nM 7.64
CHEMBL554433 — IC50 = 24.0 nM 7.62
CHEMBL301782 — IC50 = 24.0 nM 7.62
CHEMBL554756 — IC50 = 24.0 nM 7.62
CHEMBL554610 — IC50 = 25.0 nM 7.60
CHEMBL557823 — IC50 = 27.0 nM 7.57
CHEMBL300069 — IC50 = 28.0 nM 7.55
CHEMBL52904 — IC50 = 29.0 nM 7.54
CHEMBL54177 — IC50 = 32.0 nM 7.50
CHEMBL542850 — IC50 = 33.0 nM 7.48
CHEMBL553648 — IC50 = 34.0 nM 7.47