Compound Detail
CHEMBL52247
TALSUPRAM 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL52247 |
| Name | TALSUPRAM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FKHYYOUFMJBLAF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
1
Known Names
Molecular Properties
311.5
MW (Da)
4.91
ALogP
2
HBA
1
HBD
12.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 3 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Norepinephrine transporter CHEMBL304 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 6.07 | 6.07 | 850.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 5.03 | 5.03 | 9300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Norepinephrine transporter | IC50 | = | 0.79 | nM | 9.1 | Inhibition of noradrenaline uptake in rat synaptosomal fraction | 2999402 |
| Sodium-dependent serotonin transporter | IC50 | = | 850.0 | nM | 6.07 | Inhibition of 5-HT uptake in rat synaptosomal fraction | 2999402 |
| Sodium-dependent dopamine transporter | IC50 | = | 9300.0 | nM | 5.03 | Inhibition of dopamine uptake in rat synaptosomal fraction | 2999402 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2999402 | 10.1021/jm00150a012 | Sodium-dependent serotonin transporter | 2 |
| 2999402 | 10.1021/jm00150a012 | Mus musculus | 1 |
| 2999402 | 10.1021/jm00150a012 | Sodium-dependent dopamine transporter | 1 |
| 2999402 | 10.1021/jm00150a012 | Norepinephrine transporter | 1 |
Data from ChEMBL 36 via Core Engine