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Assay Detail

CHEMBL784031

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Functional
Inhibition of 5-HT uptake in rat synaptosomal fraction
ChEMBL ↗
68
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Sodium-dependent serotonin transporter (CHEMBL313) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.
Bøgesø KP, Christensen AV, Hyttel J, Liljefors T.
J Med Chem (1985) 28 : 1817 -1828
PubMed 2999402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 8.19 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL553648 — — 2 10.52
CHEMBL300069 — — 2 10.40
CHEMBL301514 — — 2 9.96
CHEMBL545671 — — 2 9.80
CHEMBL50635 — — 2 9.47
CHEMBL53635 — — 1 9.43
CHEMBL552891 — — 1 9.43
CHEMBL544266 — — 2 9.36
CHEMBL537996 — — 1 9.28
CHEMBL300019 — — 1 9.21
CHEMBL301782 — — 1 9.19
CHEMBL554756 — — 1 9.19
CHEMBL544971 — — 2 9.12
CHEMBL542117 — — 2 9.04
CHEMBL296602 INDATRALINE 2.0 2 9.00
CHEMBL553385 — — 2 8.96
CHEMBL300185 — — 1 8.92
CHEMBL52904 — — 1 8.89
CHEMBL53837 — — 2 8.80
CHEMBL545201 — — 2 8.80
CHEMBL549 CITALOPRAM 4.0 1 8.74
CHEMBL543324 — — 2 8.59
CHEMBL555549 — — 2 8.55
CHEMBL557823 — — 1 8.51
CHEMBL51224 — — 1 8.40
CHEMBL554610 — — 1 8.38
CHEMBL552808 — — 2 8.37
CHEMBL542850 — — 2 8.34
CHEMBL553384 — — 1 8.33
CHEMBL554433 — — 2 8.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL553648 — IC50 = 0.03 nM 10.52
CHEMBL300069 — IC50 = 0.04 nM 10.40
CHEMBL301514 — IC50 = 0.11 nM 9.96
CHEMBL300069 — IC50 = 0.14 nM 9.85
CHEMBL545671 — IC50 = 0.16 nM 9.80
CHEMBL545671 — IC50 = 0.28 nM 9.55
CHEMBL50635 — IC50 = 0.34 nM 9.47
CHEMBL53635 — IC50 = 0.37 nM 9.43
CHEMBL552891 — IC50 = 0.37 nM 9.43
CHEMBL544266 — IC50 = 0.44 nM 9.36
CHEMBL544266 — IC50 = 0.48 nM 9.32
CHEMBL537996 — IC50 = 0.53 nM 9.28
CHEMBL553648 — IC50 = 0.58 nM 9.24
CHEMBL300019 — IC50 = 0.62 nM 9.21
CHEMBL301782 — IC50 = 0.64 nM 9.19
CHEMBL50635 — IC50 = 0.64 nM 9.19
CHEMBL554756 — IC50 = 0.65 nM 9.19
CHEMBL544971 — IC50 = 0.75 nM 9.12
CHEMBL542117 — IC50 = 0.91 nM 9.04
CHEMBL296602 INDATRALINE IC50 = 1.0 nM 9.00
CHEMBL553385 — IC50 = 1.1 nM 8.96
CHEMBL300185 — IC50 = 1.2 nM 8.92
CHEMBL52904 — IC50 = 1.3 nM 8.89
CHEMBL53837 — IC50 = 1.6 nM 8.80
CHEMBL545201 — IC50 = 1.6 nM 8.80
CHEMBL549 CITALOPRAM IC50 = 1.8 nM 8.74
CHEMBL53837 — IC50 = 2.0 nM 8.70
CHEMBL544971 — IC50 = 2.3 nM 8.64
CHEMBL545201 — IC50 = 2.3 nM 8.64
CHEMBL301514 — IC50 = 2.5 nM 8.60
CHEMBL553385 — IC50 = 2.5 nM 8.60
CHEMBL543324 — IC50 = 2.6 nM 8.59
CHEMBL555549 — IC50 = 2.8 nM 8.55
CHEMBL557823 — IC50 = 3.1 nM 8.51
CHEMBL51224 — IC50 = 4.0 nM 8.40
CHEMBL554610 — IC50 = 4.2 nM 8.38
CHEMBL552808 — IC50 = 4.3 nM 8.37
CHEMBL542850 — IC50 = 4.6 nM 8.34
CHEMBL553384 — IC50 = 4.7 nM 8.33
CHEMBL296602 INDATRALINE IC50 = 5.2 nM 8.28
CHEMBL554433 — IC50 = 6.2 nM 8.21
CHEMBL544500 — IC50 = 6.8 nM 8.17
CHEMBL541549 — IC50 = 9.5 nM 8.02
CHEMBL555549 — IC50 = 13.0 nM 7.89
CHEMBL555597 — IC50 = 18.0 nM 7.75
CHEMBL545435 — IC50 = 20.0 nM 7.70
CHEMBL542117 — IC50 = 21.0 nM 7.68
CHEMBL542121 — IC50 = 21.0 nM 7.68
CHEMBL554433 — IC50 = 33.0 nM 7.48
CHEMBL543324 — IC50 = 36.0 nM 7.44