Assay Detail
Functional
CHEMBL783118
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Effective concentration in vitro as electropharmacological activity in the rat cortical wedge preparation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.88 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | — | 1 | 5.46 |
| CHEMBL280585 | — | — | 1 | 5.37 |
| CHEMBL420125 | — | — | 1 | 5.10 |
| CHEMBL111651 | — | — | 1 | 4.89 |
| CHEMBL113180 | — | — | 1 | 4.32 |
| CHEMBL112755 | — | — | 1 | 4.16 |
| CHEMBL112402 | — | — | 1 | - |
| CHEMBL325096 | — | — | 1 | - |
| CHEMBL286204 | QUINOLINIC ACID | — | 1 | - |
| CHEMBL323052 | — | — | 1 | - |
| CHEMBL418837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL280585 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL420125 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL111651 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL113180 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL112755 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL112402 | — | EC50 | = | 110000.0 | nM | - |
| CHEMBL325096 | — | EC50 | = | 2500000.0 | nM | - |
| CHEMBL286204 | QUINOLINIC ACID | EC50 | = | 1500000.0 | nM | - |
| CHEMBL323052 | — | EC50 | > | 5000000.0 | nM | - |
| CHEMBL418837 | — | EC50 | > | 5000000.0 | nM | - |