Assay Detail
Functional
CHEMBL796594
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Compound was tested in vitro for [Ca2+] antagonistic activity in K+-depolarized isolated rat aorta
27
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 2. Structure-activity relationships of thiazolidinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.41 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107949 | — | — | 3 | 7.48 |
| CHEMBL321372 | — | — | 1 | 7.44 |
| CHEMBL105937 | — | — | 1 | 7.20 |
| CHEMBL104689 | — | — | 1 | 7.11 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 7.00 |
| CHEMBL106536 | — | — | 1 | 6.85 |
| CHEMBL317232 | — | — | 1 | 6.80 |
| CHEMBL421225 | — | — | 1 | 6.80 |
| CHEMBL107139 | — | — | 1 | 6.70 |
| CHEMBL107623 | — | — | 1 | 6.68 |
| CHEMBL107327 | — | — | 1 | 6.55 |
| CHEMBL431040 | — | — | 1 | 6.55 |
| CHEMBL108219 | — | — | 1 | 6.50 |
| CHEMBL431062 | — | — | 1 | 6.50 |
| CHEMBL322098 | — | — | 1 | 6.44 |
| CHEMBL107854 | — | — | 1 | 6.35 |
| CHEMBL325138 | — | — | 1 | 6.25 |
| CHEMBL104257 | — | — | 1 | 6.20 |
| CHEMBL107199 | — | — | 1 | 6.10 |
| CHEMBL104859 | — | — | 1 | 5.64 |
| CHEMBL317858 | — | — | 1 | 5.58 |
| CHEMBL320051 | — | — | 1 | 5.39 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 4.71 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 4.22 |
| CHEMBL106451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107949 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL321372 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL107949 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL105937 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL104689 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL106536 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL317232 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL421225 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL107139 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL107623 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL107327 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL431040 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL108219 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL431062 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL107949 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL322098 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL107854 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL325138 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL104257 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL107199 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL104859 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL317858 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL320051 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL47 | ALPHA-TOCOPHEROL | IC50 | = | 60200.0 | nM | 4.22 |
| CHEMBL106451 | — | IC50 | > | 10000.0 | nM | - |