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Compound Detail

CHEMBL107623

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CN(CCCCN1C(=O)CSC1c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)CCOc1ccc2c(c1)OCO2

Basic Information

ChEMBL ID CHEMBL107623
Phase Preclinical
Structure Type MOL
InChI Key DNGKALAOBQCDPL-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

556.8
MW (Da)
6.08
ALogP
7
HBA
1
HBD
71.5
PSA (Ų)
0.36
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H44N2O5S
MW 556.77
Aromatic Rings 2
Heavy Atoms 39
NP-Likeness -0.59

Activity Summary

IC50 2 meas. best 6.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Rattus norvegicus
CHEMBL376
IC50 6.68 6.34 210.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10447958 10.1021/jm9900927 Rattus norvegicus 2

Data from ChEMBL 36 via Core Engine