Assay Detail
Functional
CHEMBL803471
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Compound was tested for [Ca2+] overload inhibitory activity in the veratridine-induced [Ca2+] overload model of rat cardiac myocytes.
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 2. Structure-activity relationships of thiazolidinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.26 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107949 | — | — | 3 | 7.50 |
| CHEMBL107139 | — | — | 1 | 6.50 |
| CHEMBL104689 | — | — | 1 | 6.50 |
| CHEMBL105937 | — | — | 1 | 6.50 |
| CHEMBL106536 | — | — | 1 | 6.50 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 6.05 |
| CHEMBL107623 | — | — | 1 | 6.00 |
| CHEMBL107854 | — | — | 1 | 6.00 |
| CHEMBL421225 | — | — | 1 | 6.00 |
| CHEMBL321372 | — | — | 1 | 6.00 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 4.88 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107949 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL107139 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL107949 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL104689 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL105937 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL107949 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL106536 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL107623 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL107854 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL421225 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL321372 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL47 | ALPHA-TOCOPHEROL | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL23 | DILTIAZEM | IC50 | > | 10000.0 | nM | - |