Assay Detail
Binding
CHEMBL804960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards sigma opioid receptor was determined in guinea pig cerebral homogenate using [3H]haloperidol as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and exploitation of the sigma-opiate pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.77 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20302 | — | — | 1 | 8.32 |
| CHEMBL20626 | — | — | 1 | 7.77 |
| CHEMBL278585 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20302 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL20626 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL278585 | — | Ki | = | 61.0 | nM | 7.21 |