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Compound Detail

CHEMBL278585

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C[C@H](Cc1ccccc1)NCCc1ccccc1

Basic Information

ChEMBL ID CHEMBL278585
Phase Preclinical
Structure Type MOL
InChI Key MRVIUBHXZKIUJZ-OAHLLOKOSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

239.4
MW (Da)
3.45
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H21N
MW 239.36
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -0.39

Activity Summary

Ki 4 meas. best 7.87

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 7.87 7.4333 13.6 3
Sigma non-opioid intracellular receptor 1
CHEMBL3602
Ki 7.34 7.34 46.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1848295 10.1021/jm00107a033 Sigma non-opioid intracellular receptor 1 3
8164264 10.1021/jm00034a020 Sigma non-opioid intracellular receptor 1 1

Data from ChEMBL 36 via Core Engine